Single-nuclei RNA sequencing (snRNA-seq) uncovers trophoblast cell types and lineages in the mature bovine placenta

KM Davenport, MS Ortega, H Liu… - Proceedings of the …, 2023 - National Acad Sciences
… specific cell type populations and their individual transcriptome profiles with snRNA-seq
The snRNA-seq analysis identified major cell types in the two different areas of the chorion …

Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy

M Wang, Y Liu, R Sun, F Liu, J Li, L Yan, J Zhang… - Nature Genetics, 2024 - nature.com
… The utilization of single-nucleus RNA sequence (snRNA-seq… These findings together with
the eGRNs we uncovered lay the … In brief, single nuclei were suspended in PBS containing 0.04…

Single nuclei RNA-seq of mouse placental labyrinth development

B Marsh, R Blelloch - Elife, 2020 - elifesciences.org
… by performing single nuclei RNA sequencing (snRNA-seq) at … In this study, we used
snRNA-seq to profile the murine … each placental population, uncovering candidate regulators of …

Integrative snRNA-seq and snATAC-seq profiling revealed the dynamic nuclear heterogeneity and lineage-specific regulatory architecture of the human placental …

H Wang, M Wang, Y Liu, F Liu, J Zhang, L Yan, Y Wang… - 2022 - researchsquare.com
… the three major trophoblast cell types indispensable for … uncovered dynamic molecular
pro les of the placental cells … bulk ATAC tracks matching single nuclei gene expression data. …

Single-cell RNA-seq revealed diverse cell types in the mouse placenta at mid-gestation

X Zhou, Y Xu, S Ren, D Liu, N Yang, Q Han… - Experimental Cell …, 2021 - Elsevier
… -cell RNA-seq (scRNA-seq) is a powerful tool in uncoveringcells via performing single nuclei
RNA-seq (snRNA-seq) [13]. However… For the trophoblast groups, trophoblast differentiation …

Cellular complexity of hemochorial placenta: stem cell populations, insights from scRNA-seq, and SARS-CoV-2 susceptibility

CS Mallery, M Carrillo, A Mei, A Correia-Branco… - Current Stem Cell …, 2021 - Springer
… -cell RNA sequencing (scRNA-seq) has begun to build on this foundation by uncovered
methods, Marsh and Blelloch employed single nuclei RNA-seq (snRNA-seq) in lieu of scRNA-…

Leveraging Optimized Transcriptomic and Personalized Stem Cell Technologies to Better Understand Syncytialization Defects in Preeclampsia

S Choi, T Khan, RM Roberts, DJ Schust - Frontiers in Genetics, 2022 - frontiersin.org
trophoblast (TB) sublineage development. The application of transcriptomic approaches
to these models has uncovered … leveraging of single nuclei RNA sequencing (snRNA-seq) …

Disturbed trophoblast transition links preeclampsia progression from placenta to the maternal syndrome

O Nonn, O Debnath, DS Valdes, K Sallinger… - bioRxiv, 2022 - biorxiv.org
… Here we integrated single nuclei RNA sequencing (snRNA-seq… Dynamic genes in vCCT
lineage as calculated in snRNA-seq … The gene products uncovered in this study, as described …

Single-cell insights into development of the bovine placenta

KM Davenport, EV O'Neil, MS Ortega… - Biology of …, 2024 - academic.oup.com
… of cytotrophoblast trophoblast fate in the human placenta [60, 61]. The two different BNC …
and separate lineages were previously characterized from single-nuclei RNA sequencing of …

Spatiotemporally resolved transcriptome atlas of developing mouse placenta reveals mechanisms of embryonic lethality.

Y Fu, X Zeng, Y Liu, S Jia, Y Jiang, J Tan, Y Yuan, T Xia… - bioRxiv, 2024 - biorxiv.org
… We performed a reclustering analysis of snRNAseq data and … This knowledge is instrumental
in uncovering the genetic … for single nuclei RNA sequencing support. This work was …