… We then investigated the possibility of obtaining phenothiazine-containing FTIs able to
coordinate with the zinc atom of the protein via chelating groups and to interact with the A 2 …

… We then investigated the possibility of obtaining phenothiazine-containing FTIs able to
coordinate with the zinc atom of the protein via chelating groups and to interact with the A 2 …

… This highlights the importance of the phenothiazine moiety and explains the higher affinity
towards human FTase obtained with phenothiazine-containing ylides 17 compared to …

… In this study, we have synthesized and evaluated new … -Tyr) unit as human farnesyltransferase
inhibitors. These structural … in vitro inhibition activities in the micromolar range. Propargyl …

… described for the first time phenothiazinecontaining inhibitors of protein farnesyltransferase
(FTase) [… thiol group for a set of proteins, causing their localization on the plasma membrane. …

… 1 from compound 1 to 24) and benzonitrile analogs (series 2 from compound 25 to 66) by
Deeb et al., [177]. This research group proposed four compounds from the analysis, which had …

… Search for protein farnesyltransferase inhibitors of microbial origin: our strategy and results
as well as the results obtained by … Farnesyltransferase inhibitors inhibit the growth of malaria …

… Starting from these premises, our group designed PEGylated phenothiazine derivatives
as new building blocks for anticancer drugs. PEG has been bonded to the phenothiazine …

… into researcher attention another potential anticancer mechanism, that is, inhibition of
enzymes with a key role in tumor cell proliferation, such as farnesyltransferase [26,29,30,31]. …

… The bivalent compound 8 containing guanidine was synthesized with FTI-276, and biological
evaluation showed that the methyl ester form compound 8b could inhibit the formation of …