… What are the implications of our findings for the ability of the HBV-specific CD8 cells to cope
with viral mutations and for the pathogenesis of HBV infection? The results obtained in acute …

… virus-specific CD8 + T cells clear the viral infection by killing … T-cell response to hepatitis
B core antigen in T-cell receptor … the clinical observation that viral mutations precluding the …

… , patients with chronic HBV infection have severe quantitative … –electroporated T cells to
recognize different viral mutants was … T cells (6) and the ability of HBV c18 CD8 + T cell lines to …

… virus-specific CD8 + T cells present during the early infection … ) molecule binding, as well
as T-cell receptor recognition. … viral escape mutations to viral persistence. It was shown that …

… of sustained virus-specific CD4+ helper T cell immunity is … if they are located at the interface
of the T cell receptor (TcR) … with chronic hepatitis B [83], but whether they are important for …

… Escape mutations were more often associated with HLA-B alleles. … (2 with chronic hepatitis
B virus infection, 1 with autoimmune … Limited T cell receptor diversity of HCV-specific T cell …

… avidity for T cells displaying the appropriate T cell receptor. … the use of HBV-specific tetramers
during acute HBV infection … not reveal any mutations that could abrogate T cell recognition (…

… complex to a cognate T cell receptor (TCR) (Figure 3, box 4). … compensatory mutations that
are associated with CD8+ T cell-… immunodeficiency virus-specific CD8 + T-cell responses …

… response-associated mutations of the viruses from the single-… T-cell recognition by T-cell
receptors (9, 14, 15). However, several virus-specific CTL epitopes can be recognized by T cells …

… T cell receptor … anti-HBs in patients found to harbour escape mutations of HBsAg 11. In this
setting, a … virus-specific CD8+ T cells has been reported to dominate the response 41, 77; (iii) …