HGF/MET Axis induces tumor secretion of tenascin-C and promotes stromal rewiring in pancreatic cancer

C Modica, M Olivero, F Zuppini, M Milan, C Basilico… - Cancers, 2021 - mdpi.com
… receptor by its ligand, the hepatocyte growth factor (HGF), … pair sustains the interaction
between cancer cells and the … acts as a pro-invasive factor on pancreatic cancer cells, little is …

Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model

F Brandes, K Schmidt, C Wagner, J Redekopf… - BMC cancer, 2015 - Springer
… were stimulated with hepatocyte growth factor (HGF). … invasiveness, motility and resistance
to gemcitabine therapy [12,… in MiaPaCa2(G250) cells under hypoxic conditions. This is of …

Crosstalk between tumor and stromal cells in pancreatic ductal adenocarcinoma

N Sperb, M Tsesmelis, T Wirth - International journal of molecular …, 2020 - mdpi.com
into myofibroblasts through the accumulation of the hypoxia-… and invasiveness of primary
pancreatic cancer stem cells. In … -1, and hepatocyte growth factor (HGF), which increase the …

Paracrine HGF promotes EMT and mediates the effects of PSC on chemoresistance by activating c-Met/PI3K/Akt signaling in pancreatic cancer in vitro

J Xu, S Liu, X Yang, S Cao, Y Zhou - Life Sciences, 2020 - Elsevier
… (PC) by secreting hepatocyte growth factor (HGF). The … modulate proliferation, invasion
and migration of cancer cells [24,25]… hypoxia, which becomes a self-perpetuating hypoxia-fibrosis …

Hypoxic stellate cells of pancreatic cancer stroma regulate extracellular matrix fiber organization and cancer cell motility

M Sada, K Ohuchida, K Horioka, T Okumura… - Cancer letters, 2016 - Elsevier
… , migration, and invasion of cancer cells. Moreover, ECM in … interactions with cells that are
required for key cellular events… alignment in the tumor stromal [46] because a growing body of …

Hypoxia induces tumor aggressiveness and the expansion of CD133-positive cells in a hypoxia-inducible factor-1α-dependent manner in pancreatic cancer cells

O Hashimoto, K Shimizu, S Semba, S Chiba, Y Ku… - Pathobiology, 2011 - karger.com
… K, Koga Y, Miyazaki K: Tumor-stromal cell interaction under hypoxia increases the
invasiveness of pancreatic cancer cells through the hepatocyte growth factor/c-Met pathway. Int J …

[HTML][HTML] Functions of pancreatic stellate cell-derived soluble factors in the microenvironment of pancreatic ductal carcinoma

Q Wu, Y Tian, J Zhang, H Zhang, F Gu, Y Lu, S Zou… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… -derived factor-1, hepatocyte growth factor and galectin-1. … , plays a crucial role in tumorstromal
interactions [82]. In … inhibited the invasion and metastasis of pancreatic cancer cells both …

HGF/c-MET axis in tumor microenvironment and metastasis formation

A Spina, V De Pasquale, G Cerulo, P Cocchiaro… - Biomedicines, 2015 - mdpi.com
… , Hepatocyte Growth Factor (HGF) is released by many cell … role in tumor stromal-interactions
under hypoxia [71,72,73]. … also the c-MET expression in pancreatic cancer cells PK8 [76]. …

The impact of the activated stroma on pancreatic ductal adenocarcinoma biology and therapy resistance

M Erkan, C Reiser-Erkan, CW Michalski… - Current molecular …, 2012 - ingentaconnect.com
… fibrotic/hypoxic milieu of pancreatic cancer through abnormal … dramatic rearrangement of
tumor-stromal interactions. It has … hepatocyte growth factor—in pancreatic stromal cells causes …

Pancreatic stellate cells: Aiding and abetting pancreatic cancer progression

SP Pothula, RC Pirola, JS Wilson, MV Apte - Pancreatology, 2020 - Elsevier
… of organotypic pancreatic tissue cultured under hypoxic … facilitate the invasion and co-migration
of cancer cells through the … PSCs secrete the precursor form of hepatocyte growth factor (…