… development of new iPSC-derived NK cell therapies, with a focus on improved targeting of
cancer. We then discuss improvements in methods to expand iPSC-derived NK cells and how …

… , Natural Killer (NK) cell-based immunotherapy has become a promising approach to target
… of UCB mature NK cells and UCB-HSPC- or UCB-iPSC-derived NK cells and about their …

… Allogeneic natural killer (NK) cell adoptive transfer has shown clinical benefit in patients
with cancer. These cells can recognize and kill tumor cells in an antigen-specific manner by …

… cell targeting, eg, ADCC enhanced antibodies, bi- or tri-specifics, and iPSC-derived NK cells
… FT596 (140), is an iPSC-derived CAR-NK cell therapy armed with three modalities: a CD19-…

… NKCs induce apoptosis of target cells by secreting perforin, granzyme, cytokines and …
Broadly, NK cell infiltration, solid tumor targeting, in vivo persistence and resistance to TME must …

… Natural killer (NK) cells have gained attention as a promising adoptive cell therapy platform
… In contrast, the CD56 dim subset exhibits higher direct cell cytotoxicity against tumor targets, …

… Natural killer (NK) cell immunotherapies for cancer can … A particular focus is on iPSC-derived
cell products that can be … Direct binding to target cell ligands by a combination of natural …

… These NK cells have poor ability to kill tumor cell targets but play an important role in
modulating immune responses through the secretion of regulatory cytokines, like IFN-γ (17, 18). …

… sensitization, natural killer (NK) cells have necessitated use of … NK cells perform effector
responses against target cells, as is … Use of CAR-transduced natural killer cells in CD19-positive …