Genome editing in engineered T cells for cancer immunotherapy
, … and CAR T Cells Scientific Committee of … - Human Gene …, 2023 - liebertpub.com
… for targeted transgene integration in primary T cells, 31 and … There had been concerns about
triggering natural killer (NK)-… CAR T cells, 107 but the majority of iPSC-derived CAR T cells …
triggering natural killer (NK)-… CAR T cells, 107 but the majority of iPSC-derived CAR T cells …
Engineering of potent CAR NK cells using non-viral Sleeping Beauty transposition from minimalistic DNA vectors
T Bexte, L Botezatu, C Miskey, F Gierschek, A Moter… - Molecular Therapy, 2024 - cell.com
… leukemia and lymphoma samples as targets in vitro and in vivo … CAR-engineered natural
killer (NK) cells hold the potential to … NK-92 cell lines49,50 and of iPSC-derived NK-cells,51 but …
killer (NK) cells hold the potential to … NK-92 cell lines49,50 and of iPSC-derived NK-cells,51 but …
The fulfilled promise and unmet potential of umbilical cord blood
J Ropa, W Van't Hof - Current Opinion in Hematology, 2024 - journals.lww.com
… T-/CAR natural killer (NK)-cell … of iPSC-derived modified NK cell therapy products displaying
optimized potential for expansion and preservation after transplant, and targeted tumor cell …
optimized potential for expansion and preservation after transplant, and targeted tumor cell …
OPEN ACCESS EDITED BY
H Einsele, A Steinle, S Berglund, X Chen… - NK cell modifications …, 2023 - books.google.com
… Multifunctional natural killer cell engagers targeting NKp46 trigger protective tumor
immunity… Human iPSC-derived natural killer cells engineered with chimeric antigen receptors …
immunity… Human iPSC-derived natural killer cells engineered with chimeric antigen receptors …
Advanced Strategies of CAR-T Cell Therapy in Solid Tumors and Hematological Malignancies
Y Liu, C Peng, F Ahad, SA Ali Zaidi… - Recent Patents on …, 2024 - ingentaconnect.com
… In vitro studies have shown that CAR-NK cells targeting EGFR effectively eradicate breast
cancer cells [141]. Tissue factor-focused natural killer cells have demonstrated notable …
cancer cells [141]. Tissue factor-focused natural killer cells have demonstrated notable …
Application potentials of the iPSC technology in modeling, drug discovery and regeneration of skeletal system disorders
G Zhou - Joint and Bone, 2023 - Elsevier
… therapeutic targets, it is essential to elucidate the cellular … iPSC-derived cells were embedded
before cell transplantation. It has been demonstrated, repeatedly, that iPSC-derived cells …
before cell transplantation. It has been demonstrated, repeatedly, that iPSC-derived cells …
Nanobody-based CAR NK cells for possible immunotherapy of MICA+ tumors
ER Verhaar, WJC van Keizerswaard, A Knoflook… - PNAS …, 2024 - academic.oup.com
… iPSC-Derived natural killer cell therapies—expansion and targeting. Front Immunol. 13:…
Human iPSC-derived natural killer cells engineered with chimeric antigen receptors enhance anti…
Human iPSC-derived natural killer cells engineered with chimeric antigen receptors enhance anti…
Generation and optimization of off-the-shelf immunotherapeutics targeting TCR-Vβ2+ T cell malignancy
J Ren, X Liao, JM Lewis, J Chang, R Qu… - Nature …, 2024 - nature.com
… cells to target malignant T cells in vivo, we generated a patient-derived xenograft (PDX) model
in NSG mice (Fig. 2a) populated with total CD4 T cells … of iPSC-derived NK cell production …
in NSG mice (Fig. 2a) populated with total CD4 T cells … of iPSC-derived NK cell production …
Small extracellular vesicles derived from induced pluripotent stem cells in the treatment of myocardial injury
WT Meng, HD Guo - International Journal of Molecular Sciences, 2023 - mdpi.com
… iPSC-derived small extracellular vesicles (iPSCs-sEVs) can carry genetic and proteinaceous
substances and mediate the interaction between iPSCs and target cells. In recent years, …
substances and mediate the interaction between iPSCs and target cells. In recent years, …