Publisher Summary This chapter discusses the antibodies that recognize nitrotyrosine.
Peroxynitrite is a potent oxidant that reacts with a variety of biological molecules, oxidizing
thiols, initiating lipid peroxidation, inactivating ion channels, and damaging DNA. Tyrosine
nitration can inactivate enzymes and receptors that depend on tyrosine residues for their
activity. Nitration prevents phosphorylation of tyrosine residues important for signal
transduction. Nitration of phenolics by peroxynitrite occurs spontaneously however is also …