Emergence of rapid drug resistance to existing antimalarial drugs in Plasmodium falciparum
has created the need for prediction of novel targets as well as leads derived from original
molecules with improved activity against a validated drug target. The malaria parasite has a
plant plastid‐like apicoplast. To overcome the problem of falciparum malaria, the metabolic
pathways in parasite apicoplast have been used as antimalarial drug targets. Among
several pathways in apicoplast, isoprenoid biosynthesis is one of the important pathways for …

[1] T. Qidwai, F. Jamal, MY Khan, and B. Sharma,“Exploring Drug Targets in Isoprenoid
Biosynthetic Pathway for Plasmodium falciparum,” Biochemistry Research International, vol.
2014, Article ID 657189, 12 pages, 2014.[2] B. Zhang, KM Watts, D. Hodge et al.,“A second
target of the antimalarial and antibacterial agent Fosmidomycin revealed by cellular
metabolic profiling,” Biochemistry, vol. 50, 2011.[3] CY Botté, F. Dubar, GI McFadden, E.
Maréchal, and C. Biot,“Plasmodium falciparum Apicoplast Drugs: Targets or offtargets?” …