Loss of Klotho contributes to kidney injury by derepression of Wnt/β-catenin signaling
… We show that loss of Klotho de-represses Wnt/β-catenin signaling because Klotho physically
binds to and sequesters Wnt ligands in the kidneys. This leads to activation of a fibrogenic …
binds to and sequesters Wnt ligands in the kidneys. This leads to activation of a fibrogenic …
[HTML][HTML] Loss of Klotho contributes to cartilage damage by derepression of canonical Wnt/β-catenin signaling in osteoarthritis mice
Y Gu, K Ren, L Wang, Q Yao - Aging (Albany NY), 2019 - ncbi.nlm.nih.gov
… The over-expression of β-catenin in mature … of Klotho in chondrocytes in OA also lost its
antagonistic effect on Wnt1, 4 and 7a, which resulted in relative activation of Wnt/β-catenin and …
antagonistic effect on Wnt1, 4 and 7a, which resulted in relative activation of Wnt/β-catenin and …
[HTML][HTML] Klotho: a tumor suppressor and modulator of the Wnt/β-catenin pathway in human hepatocellular carcinoma
X Tang, Y Wang, Z Fan, G Ji, M Wang, J Lin… - Laboratory …, 2016 - Elsevier
… occurs during the late phase of cervical tumorigenesis, and consequent functional loss of
klotho contributes to aberrant activation of the canonical Wnt pathway. Therefore, we …
klotho contributes to aberrant activation of the canonical Wnt pathway. Therefore, we …
[HTML][HTML] Role of Klotho and AGE/RAGE-Wnt/β-catenin signalling pathway on the development of cardiac and renal fibrosis in diabetes
B Martín-Carro, J Martín-Vírgala… - International journal of …, 2023 - mdpi.com
… There were no differences in the renal expression of Klotho, suggesting that the lower serum
sKlotho found in the diabetic rats could be due to urinary loss as consequence of polyuria (…
sKlotho found in the diabetic rats could be due to urinary loss as consequence of polyuria (…
Expression of klotho and β-catenin in esophageal squamous cell carcinoma, and their clinicopathological and prognostic significance
X Tang, Z Fan, Y Wang, G Ji, M Wang… - Diseases of the …, 2016 - academic.oup.com
… In summary, this is the first report about the role of klotho in ESCC and its association with
β-catenin. We confirm that low expression of klotho occurs frequently in ESCC, and its loss …
β-catenin. We confirm that low expression of klotho occurs frequently in ESCC, and its loss …
Klotho gene‐modified BMSCs showed elevated antifibrotic effects by inhibiting the Wnt/β‐catenin pathway in kidneys after acute injury
F Zhang, X Wan, YZ Cao, D Sun… - Cell biology …, 2018 - Wiley Online Library
… Our study demonstrated that transplantation of Klotho-GFP-BMSCs into IRI mice ameliorated
the loss of renal function and renal interstitial fibrosis, and the renal protective effect of …
the loss of renal function and renal interstitial fibrosis, and the renal protective effect of …
Klotho as a regulator of oxidative stress and senescence
M Kuro-o - 2008 - degruyter.com
… Therefore, KL-/- mice and klotho mutant mice are collectively described as Klotho-deficient …
Despite the lack of Klotho expression in the kidney, the EFmKL48 allele was able to rescue …
Despite the lack of Klotho expression in the kidney, the EFmKL48 allele was able to rescue …
[HTML][HTML] Overexpression of Klotho suppresses liver cancer progression and induces cell apoptosis by negatively regulating wnt/β-catenin signaling pathway
H Sun, Y Gao, K Lu, G Zhao, X Li, Z Li… - World journal of surgical …, 2015 - Springer
… RT-PCR and western blotting analysis were used to detect the expression of Klotho, β-catenin…
Colony formation assay was used to test the proliferation ability in Klotho transfected cells. …
Colony formation assay was used to test the proliferation ability in Klotho transfected cells. …
Klotho-derived peptide 6 ameliorates diabetic kidney disease by targeting Wnt/β-catenin signaling
X Chen, H Tan, J Xu, Y Tian, Q Yuan, Y Zuo, Q Chen… - Kidney International, 2022 - Elsevier
… can predict the prognosis of nephropathy in type 2 diabetic patients, 16 , 17 suggesting that
loss of Klotho may have a causative role in the pathogenesis and progression of DKD. More …
loss of Klotho may have a causative role in the pathogenesis and progression of DKD. More …
Klotho to treat kidney fibrosis
… The loss of Klotho during kidney … Klotho is reduced already in stage I human CKD suggests
that there are factors that reduce Klotho synthesis by tubular epithelium beyond the loss of …
that there are factors that reduce Klotho synthesis by tubular epithelium beyond the loss of …
相关搜索
- wnt β catenin signaling
- wnt β catenin pathway
- overexpression of klotho β catenin
- role of klotho β catenin
- expression of klotho β catenin
- β catenin tcf 4 pathway
- klotho derived peptide β catenin
- β catenin signalling pathway
- osteoarthritis mice β catenin
- cartilage degradation in osteoarthritis β catenin
- human osteoarthritic chondrocytes β catenin
- cartilage damage β catenin
- tumor suppressor and modulator β catenin
- liver cancer progression β catenin
- renal fibrosis in diabetes β catenin
- development of cardiac β catenin