Usefulness of a dopamine transporter PET ligand [18F] β-CFT in assessing disability in Parkinson's disease
JO Rinne, H Ruottinen, J Bergman… - Journal of Neurology …, 1999 - jnnp.bmj.com
… of dopamine transporter ligands, such as [ 18 F]β-CFT, to … striatal uptake of dopamine
transporter ligand [ 123 I]β-CIT11 … reductions seen with [ 18 F]β-CFT. Differences in the severity of …
transporter ligand [ 123 I]β-CIT11 … reductions seen with [ 18 F]β-CFT. Differences in the severity of …
Progression in Parkinson's disease: A positron emission tomography study with a dopamine transporter ligand [18F]CFT
E Nurmi, HM Ruottinen, V Kaasinen… - Annals of Neurology …, 2000 - Wiley Online Library
… on dopamine transporter ligand uptake during progression of PD. … dopamine transporter
function with PET during the progression of PD using [18F]CFT18,19 dopamine reuptake ligand. …
function with PET during the progression of PD using [18F]CFT18,19 dopamine reuptake ligand. …
Dopamine transporter binding in rat striatum: a comparison of [O-methyl-11C] β-CFT and [N-methyl-11C] β-CFT
KK Yoder, GD Hutchins, BH Mock, X Fei… - Nuclear medicine and …, 2009 - Elsevier
… in vivo density of monoamine transporters, including the dopamine transporter (DAT). [ 11
C]β-CFT is useful for studying DAT as a marker of dopaminergic innervation in animal models …
C]β-CFT is useful for studying DAT as a marker of dopaminergic innervation in animal models …
Striatal uptake of the dopamine reuptake ligand [11C]β-CFT is reduced in Alzheimer's disease assessed by positron emission tomography
JO Rinne, N Sahlberg, H Ruottinen, K Nagren… - Neurology, 1998 - AAN Enterprises
… of various dopamine transporter ligands to … of dopamine reuptake ligand[ 11 C]β-CFT
declines with age. This is in accordance with results obtained with other ligands, such as [ 123 I]β-…
declines with age. This is in accordance with results obtained with other ligands, such as [ 123 I]β-…
Striatal uptake of a novel PET ligand, [18F]β‐CFT, is reduced in early Parkinson's disease
JO Rinne, J Bergman, H Ruottinen, M Haaparanta… - Synapse, 1999 - Wiley Online Library
… In conclusion, [18F]-CFT is a powerful ligand to demonstrate presynaptic dopaminergic defect
… CFT is more selective for dopamine transporter (compared to noradrenaline and serotonin …
… CFT is more selective for dopamine transporter (compared to noradrenaline and serotonin …
[18F]CFT ([18F]WIN 35,428), a radioligand to study the dopamine transporter with PET: Characterization in human subjects
A Laakso, J Bergman, M Haaparanta, H Vilkman… - Synapse, 1998 - Wiley Online Library
… The regional distribution of [18F]CFT correlated well for known distribution of dopaminergic
… resembled that seen with other DAT ligands in vivo, including [11C]CFT. When the time-…
… resembled that seen with other DAT ligands in vivo, including [11C]CFT. When the time-…
[18F]CFT ([18F]WIN 35,428), a radioligand to study the dopamine transporter with PET: Biodistribution in rats
… as CFT or WIN 35,428) and the biodistribution of this compound in rats. 18F-labelled CFT
has … rats with a specific dopamine transport inhibitor, GBR 12909, showed that CFT binding is …
has … rats with a specific dopamine transport inhibitor, GBR 12909, showed that CFT binding is …
… in binding site density of dopamine transporter in the striatum, orbitofrontal cortex, and amygdala in early Parkinson's disease: Compartment analysis for β‐CFT …
Y Ouchi, E Yoshikawa, H Okada… - Annals of Neurology …, 1999 - Wiley Online Library
… ligand … ligand in the brain, and specifically bound ligand in the brain.Data were analyzed
based on this three-compartment, four-parameter model, fitting for blood– brain barrier transport …
based on this three-compartment, four-parameter model, fitting for blood– brain barrier transport …
Potential of [18F]β‐CFT‐FE (2β‐carbomethoxy‐3β‐(4‐fluorophenyl)‐8‐(2‐[18F]fluoroethyl)nortropane) as a dopamine transporter ligand: A PET study in the …
N Harada, H Ohba, D Fukumoto, T Kakiuchi… - Synapse, 2004 - Wiley Online Library
… In the present study, [18F]-CFT-FE was synthesized and its potential as a PET ligand for
the quantitative imaging of DAT activity was evaluated in conscious rhesus monkeys. …
the quantitative imaging of DAT activity was evaluated in conscious rhesus monkeys. …
Structure of the human dopamine transporter and mechanisms of inhibition
DK Srivastava, V Navratna, DK Tosh, A Chinn, MF Sk… - Nature, 2024 - nature.com
… ligands 3,16 . To understand how MRS7292 inhibits dopamine transport and slows the
dissociation of ligands … of Δ-hDAT in complex with MRS7292 and β-CFT (Fig. 2a). The density is …
dissociation of ligands … of Δ-hDAT in complex with MRS7292 and β-CFT (Fig. 2a). The density is …
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