Dysregulation of Wnt signaling appears to be a critical event in the formation of intestinal
tumors and some other cancers. Accumulating data from preclinical studies strongly suggest
that targeted disruption of β-catenin-mediated TCF signaling is a promising strategy for early
chemopreventive intervention, particularly with respect to intestinal tumorigenesis. While the
search for potent inhibitors is just getting underway, the ability of several synthetic and
naturally occurring agents to decrease the transcriptional activity of a luciferase reporter …