γ-Interferon-inducible lysosomal thiol reductase (GILT) maintains phagosomal proteolysis in alternatively activated macrophages
DR Balce, ERO Allan, N McKenna, RM Yates - Journal of Biological …, 2014 - ASBMB
Although it is known that lysosomal cysteine cathepsins require a reducing environment for
optimal activity, it is not firmly established how these enzymes are maintained in their
reduced-active state in the acidic and occasionally oxidative environment within
phagosomes and lysosomes. γ-Interferon-inducible lysosomal thiol reductase (GILT) has
been the only enzyme described in the endosomes, lysosomes, and phagosomes with the
potential to catalyze the reduction of cysteine cathepsins. Our goal in the current study was …
optimal activity, it is not firmly established how these enzymes are maintained in their
reduced-active state in the acidic and occasionally oxidative environment within
phagosomes and lysosomes. γ-Interferon-inducible lysosomal thiol reductase (GILT) has
been the only enzyme described in the endosomes, lysosomes, and phagosomes with the
potential to catalyze the reduction of cysteine cathepsins. Our goal in the current study was …
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