Current classification criteria for definite antiphospholipid syndrome (APS) mandate the use
of one or more of three positive 'standardized'laboratory assays to detect antiphospholipid
antibodies (aPL)(viz: anticardiolipin [aCL] IgG and IgM; anti-β2glycoprotein I [anti-β2GPI]
antibodies IgG and IgM; and/or a lupus anticoagulant [LAC]), when at least one of the two
major clinical manifestations (thrombosis or pregnancy losses) are present. Although, efforts
of standardization for these 'criteria'aPL tests have been conducted over the last 27 years …

Current classification criteria for definite APS recommend the use of one or more of three
positive standardized laboratory assays, including anticardiolipin antibodies (aCL), lupus
anticoagulant (LA), and antibodies directed to β2glycoprotein I (anti-β2GPI) to detect
antiphospholipid antibodies (aPL) in the presence of at least one of the two major clinical
manifestations (ie, thrombosis or pregnancy morbidity) of the syndrome. Several other
autoantibodies shown to be directed to phospholipids and/or their complexes with …