19F NMR Spectroscopy for the Analysis of DNA G-Quadruplex Structures Using 19F-Labeled Nucleobase
T Ishizuka, HL Bao, Y Xu - G-Quadruplex Nucleic Acids: Methods and …, 2019 - Springer
T Ishizuka, HL Bao, Y Xu
G-Quadruplex Nucleic Acids: Methods and Protocols, 2019•SpringerG-quadruplex structures have been suggested to be biologically important in processes
such as transcription and translation, gene expression and regulation in human cancer cells,
and regulation of telomere length. Investigation of G-quadruplex structures associated with
biological events is therefore essential to understanding the functions of these molecules.
We developed the 19 F-labeled nucleobases and introduced them into DNA sequences for
the 19 F NMR spectroscopy analysis. We present the 19 F NMR methodology used in our …
such as transcription and translation, gene expression and regulation in human cancer cells,
and regulation of telomere length. Investigation of G-quadruplex structures associated with
biological events is therefore essential to understanding the functions of these molecules.
We developed the 19 F-labeled nucleobases and introduced them into DNA sequences for
the 19 F NMR spectroscopy analysis. We present the 19 F NMR methodology used in our …
Abstract
G-quadruplex structures have been suggested to be biologically important in processes such as transcription and translation, gene expression and regulation in human cancer cells, and regulation of telomere length. Investigation of G-quadruplex structures associated with biological events is therefore essential to understanding the functions of these molecules. We developed the 19F-labeled nucleobases and introduced them into DNA sequences for the 19F NMR spectroscopy analysis. We present the 19F NMR methodology used in our research group for the study of G-quadruplex structures in vitro and in living cells.
Springer
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