A general and diastereoselective fluorination/glycosylation strategy for the synthesis of 2′-fluorinated
nucleosides has been developed. Electrophilic fluorination of a glycal with NFSI …

… the 2′- and 3′-position, two analogs … 2′-deoxy-2′-fluoro nucleosides showed promising
therapeutic potential (mainly antiviral and anticancer), the synthesis of new generations of 2…

A series of 5-substituted l-(2-deoxy-2-fluoro-/3-D-arabinofuranosyl) cytosines 7a-d and their
corresponding uracils 9a-d, f were prepared by condensation of 3-0-acetyl-5-0-benzoyl-2-…

… most of the 4′-fluoro-nucleosides discussed in this review ocurrs via inhibition of viral RNA
polymerases, and this necessitates that the 4′-fluoro-nucleosides (or their corresponding …

As antiviral nucleosides containing a 2‘,3‘-unsaturated sugar moiety with 2‘-fluoro
substitution are endowed with increased stabilization of the glycosyl bond, it was of interest to …

… In 1964, Fox and co-workers first synthesized several 2′-deoxy-2′α-fluoronucleosides 13
starting from some commercially available nucleosides 10 (Scheme 3). Selective protections …

… 2) [11]. Subsequent studies showed that 2′-fluoro nucleosides were stable against
degradation by nucleases [12], then a series of 2′-deoxy-2′-fluoro nucleosides with different …

… 2'-Fluoro nucleosides have an even higher content of this conformation, namely, 80%.
The 2/-amino nucleosides, with only 20% of the N-conformation, are more akin to the …

… In 1993, Kawasaki and co-workers 81 reported the synthesis of a series of modified
phosphorothioate or phosphodiester oligonucleotides of 2′-deoxy-2′-fluoronucleosides and …

… Of even more direct concern to this report are studies of nucleoside analogues with the 2'-deoxy-2'-…
activity of some purine 2,-deoxy-2,-fluoronucleosides.47 Here we describe further …