2′-O-Methyl-8-methylguanosine as a Z-Form RNA Stabilizer for Structural and Functional Study of Z-RNA
T Balasubramaniyam, T Ishizuka, CD Xiao, HL Bao… - Molecules, 2018 - mdpi.com
T Balasubramaniyam, T Ishizuka, CD Xiao, HL Bao, Y Xu
Molecules, 2018•mdpi.comIn contrast to Z-DNA that was stabilized and well-studied for its structure by chemical
approaches, the stabilization and structural study of Z-RNA remains a challenge. In this
study, we developed a Z-form RNA stabilizer m8Gm, and demonstrated that incorporation of
m8Gm into RNA can markedly stabilize the Z-RNA at low salt conditions. Using the m8Gm-
contained Z-RNA, we determined the structure of Z-RNA and investigated the interaction of
protein and Z-RNA.
approaches, the stabilization and structural study of Z-RNA remains a challenge. In this
study, we developed a Z-form RNA stabilizer m8Gm, and demonstrated that incorporation of
m8Gm into RNA can markedly stabilize the Z-RNA at low salt conditions. Using the m8Gm-
contained Z-RNA, we determined the structure of Z-RNA and investigated the interaction of
protein and Z-RNA.
In contrast to Z-DNA that was stabilized and well-studied for its structure by chemical approaches, the stabilization and structural study of Z-RNA remains a challenge. In this study, we developed a Z-form RNA stabilizer m8Gm, and demonstrated that incorporation of m8Gm into RNA can markedly stabilize the Z-RNA at low salt conditions. Using the m8Gm-contained Z-RNA, we determined the structure of Z-RNA and investigated the interaction of protein and Z-RNA.
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