… As noted in the preamble, an independent ERC was commissioned to perform a formal
systematic review of critical clinical questions related to adult congenital heart disease (ACHD),
the results of which were considered by the writing committee for incorporation into this
guideline. Concurrent with this process, writing committee members evaluated study data
relevant to the rest of the … Where overlap exists, this document focuses on the diagnosis
and treatment of congenital valve disease when it differs from acquired valve disease …

The recommendations listed in this guideline are, whenever possible, evidence-based. An
initial extensive evidence review, which included literature derived from research involving
human subjects, published in English, and indexed in MEDLINE (through PubMed),
EMBASE,