2021 DORIS definition of remission in SLE: final recommendations from an international task force
RF van Vollenhoven, G Bertsias, A Doria… - Lupus science & …, 2021 - lupus.bmj.com
RF van Vollenhoven, G Bertsias, A Doria, D Isenberg, E Morand, MA Petri, BA Pons-Estel…
Lupus science & medicine, 2021•lupus.bmj.comObjective To achieve consensus on a definition of remission in SLE (DORIS). Background
Remission is the stated goal for both patient and caregiver, but consensus on a definition of
remission has been lacking. Previously, an international task force consisting of patient
representatives and medical specialists published a framework for such a definition, without
reaching a final recommendation. Methods Several systematic literature reviews were
performed and specific research questions examined in suitably chosen data sets. The …
Remission is the stated goal for both patient and caregiver, but consensus on a definition of
remission has been lacking. Previously, an international task force consisting of patient
representatives and medical specialists published a framework for such a definition, without
reaching a final recommendation. Methods Several systematic literature reviews were
performed and specific research questions examined in suitably chosen data sets. The …
Objective
To achieve consensus on a definition of remission in SLE (DORIS).
Background
Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation.
Methods
Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets. The findings were discussed, reformulated as recommendations and voted on.
Results
Based on data from the literature and several SLE-specific data sets, a set of recommendations was endorsed. Ultimately, the DORIS Task Force recommended a single definition of remission in SLE, based on clinical systemic lupus erythematosus disease activitiy index (SLEDAI)=0, Evaluator’s Global Assessment <0.5 (0–3), prednisolone 5 mg/day or less, and stable antimalarials, immunosuppressives, and biologics.
Conclusion
The 2021 DORIS definition of remission in SLE is recommended for use in clinical care, education, and research including clinical trials and observational studies.
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