It is a well-established fact that the anatomically modern human originated in Africa about 200 thousand years ago (KYA) and migrated out-of-Africa about 60–70 KYA. In this process, several populations arose and each of them has their own evolutionary history. Genetic drift, endogamy practices, admixture, and natural selection are examples of a few evolutionary phenomena leading to genetic diversity among populations around the world including susceptibility and resistance to genetic diseases, infectious diseases, therapeutic response to drugs, etc. Understanding these phenomena is much more relevant in a country like India, which has the richest ethnic, cultural, linguistic, and social diversity in the world and harbors 4635 anthropologically well-defined populations, among which 532 are tribes, including 72 primitive tribes (36 hunters and gatherers). In simple terms, there are populations in India who are phenotypically similar to Africans (Andamanese), some are similar to Europeans, some are similar to southeast Asians, and some are not related to any populations outside India. Most interestingly, Indian populations differ from each other with respect to their social structure, language, marriage practices, dress and food habits, physical appearance, etc. They are inhabitated in a variety of the geographical realms, ranging from scorching desert to evergreen forest, fertile plains to the southern dry plateaus, lowlands to the breath-taking high Himalayas. Broadly, Indians speak four major families of languages: Indo-European, Dravidian, Austroasiatic, and Tibeto-Burman. In addition, India has two distinguished isolated languages, namely Andamanese and Nihalis spoken in Andaman and Nicobar Islands, and pockets of Madhya Pradesh and Maharashtra, respectively. In addition to the indigenous populations, India experienced migration of several populations in the recent past. With everything mentioned above about India, it is tempting to say that India is an “ethnic museum.” This chapter

Genome-Wide Association Studies: From Polymorphism to Personalized Medicine, ed. K. Appasani. Published by Cambridge University Press.© Cambridge University Press 2016.