[HTML][HTML] 3D viscoelastic drag forces contribute to cell shape changes during organogenesis in the zebrafish embryo
PC Sanematsu, G Erdemci-Tandogan, H Patel… - Cells & …, 2021 - Elsevier
The left-right organizer in zebrafish embryos, Kupffer's Vesicle (KV), is a simple organ that
undergoes programmed asymmetric cell shape changes that are necessary to establish the
left-right axis of the embryo. We use simulations and experiments to investigate whether 3D
mechanical drag forces generated by the posteriorly-directed motion of the KV through the
tailbud tissue are sufficient to drive such shape changes. We develop a fully 3D vertex-like
(Voronoi) model for the tissue architecture, and demonstrate that the tissue can generate …
undergoes programmed asymmetric cell shape changes that are necessary to establish the
left-right axis of the embryo. We use simulations and experiments to investigate whether 3D
mechanical drag forces generated by the posteriorly-directed motion of the KV through the
tailbud tissue are sufficient to drive such shape changes. We develop a fully 3D vertex-like
(Voronoi) model for the tissue architecture, and demonstrate that the tissue can generate …
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