4-Hydroxynonenal induces adaptive response and enhances PC12 cell tolerance primarily through induction of thioredoxin reductase 1 via activation of Nrf2
4-Hydroxynonenal (4-HNE) is one of the major end products of lipid peroxidation. It has
been widely accepted that 4-HNE can induce oxidative stress, implicating into extensive
stress-related diseases. In the present study, however, 4-HNE was found to exert adaptive
cytoprotective effect at low concentrations, which was primarily through induction of
thioredoxin reductase 1 (TR1) via transcriptional activation of NF-E2-related factor 2 (Nrf2).
Pretreatment with 4-HNE at sublethal concentrations significantly protected PC12 cells …
been widely accepted that 4-HNE can induce oxidative stress, implicating into extensive
stress-related diseases. In the present study, however, 4-HNE was found to exert adaptive
cytoprotective effect at low concentrations, which was primarily through induction of
thioredoxin reductase 1 (TR1) via transcriptional activation of NF-E2-related factor 2 (Nrf2).
Pretreatment with 4-HNE at sublethal concentrations significantly protected PC12 cells …
以上显示的是最相近的搜索结果。 查看全部搜索结果