Inhibition of hypoxia-inducible carbonic anhydrase-IX enhances hexokinase II inhibitor-induced hepatocellular carcinoma cell apoptosis
Aim: The hypoxic condition within large or infiltrative hypovascular tumors produces
intracellular acidification, which could activate many signaling pathways and augment
cancer cell growth and invasion. Carbonic anhydrase-IX (CA-IX) is an enzyme lowering pH.
This study is to examine whether hypoxia induces CA-IX in hepatocellular carcinoma (HCC)
cells, and to evaluate its clinical implication in HCC patients. Methods: Human HCC cell
lines (Huh-7 and HepG2 cells) were used, and cell growth was assessed using MTS assay …
intracellular acidification, which could activate many signaling pathways and augment
cancer cell growth and invasion. Carbonic anhydrase-IX (CA-IX) is an enzyme lowering pH.
This study is to examine whether hypoxia induces CA-IX in hepatocellular carcinoma (HCC)
cells, and to evaluate its clinical implication in HCC patients. Methods: Human HCC cell
lines (Huh-7 and HepG2 cells) were used, and cell growth was assessed using MTS assay …
[引用][C] 445 INHIBITION OF HYPOXIA-INDUCIBLE CARBONIC ANHYDRASE IX ENHANCES HEXOKINASE II INHIBITOR-INDUCED HEPATOCELLULAR …
445 INHIBITION OF HYPOXIA-INDUCIBLE CARBONIC ANHYDRASE IX ENHANCES
HEXOKINASE II INHIBITOR-INDUCED HEPATOCELLULAR CARCINOMA CELL
APOPTOSIS … 445 INHIBITION OF HYPOXIA-INDUCIBLE CARBONIC ANHYDRASE IX
ENHANCES HEXOKINASE II INHIBITOR-INDUCED HEPATOCELLULAR CARCINOMA
CELL APOPTOSIS … Journal of Hepatology > 2008 > 48 > Supplement 2 > S170 …
HEXOKINASE II INHIBITOR-INDUCED HEPATOCELLULAR CARCINOMA CELL
APOPTOSIS … 445 INHIBITION OF HYPOXIA-INDUCIBLE CARBONIC ANHYDRASE IX
ENHANCES HEXOKINASE II INHIBITOR-INDUCED HEPATOCELLULAR CARCINOMA
CELL APOPTOSIS … Journal of Hepatology > 2008 > 48 > Supplement 2 > S170 …