A Direct Entry to Substituted N‐Methoxyamines from N‐Methoxyamides via N‐Oxyiminium Ions
K Shirokane, Y Kurosaki, T Sato, N Chida - … Chemie International Edition, 2010 - infona.pl
K Shirokane, Y Kurosaki, T Sato, N Chida
Angewandte Chemie International Edition, 2010•infona.plTake the direct path: Sequential nucleophilic addition of N‐methoxyamides using DIBAL and
organometallic reagents provided substituted N‐methoxyamines in one pot via five‐
membered chelated intermediates (see scheme, DIBAL= diisobutylaluminum hydride). The
reaction allows functionalization of acyclic amides and macrolactams without a preactivation
step, which is generally required for inert amide carbonyl groups.
organometallic reagents provided substituted N‐methoxyamines in one pot via five‐
membered chelated intermediates (see scheme, DIBAL= diisobutylaluminum hydride). The
reaction allows functionalization of acyclic amides and macrolactams without a preactivation
step, which is generally required for inert amide carbonyl groups.
Take the direct path: Sequential nucleophilic addition of N‐methoxyamides using DIBAL and organometallic reagents provided substituted N‐methoxyamines in one pot via five‐membered chelated intermediates (see scheme, DIBAL=diisobutylaluminum hydride). The reaction allows functionalization of acyclic amides and macrolactams without a preactivation step, which is generally required for inert amide carbonyl groups.
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