A High-Throughput screen identifies DYRK1A inhibitor ID-8 that stimulates human kidney tubular epithelial cell proliferation
Background The death of epithelial cells in the proximal tubules is thought to be the primary
cause of AKI, but epithelial cells that survive kidney injury have a remarkable ability to
proliferate. Because proximal tubular epithelial cells play a predominant role in kidney
regeneration after damage, a potential approach to treat AKI is to discover regenerative
therapeutics capable of stimulating proliferation of these cells. Methods We conducted a
high-throughput phenotypic screen using 1902 biologically active compounds to identify …
cause of AKI, but epithelial cells that survive kidney injury have a remarkable ability to
proliferate. Because proximal tubular epithelial cells play a predominant role in kidney
regeneration after damage, a potential approach to treat AKI is to discover regenerative
therapeutics capable of stimulating proliferation of these cells. Methods We conducted a
high-throughput phenotypic screen using 1902 biologically active compounds to identify …
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