Abstract Rationale A common MUC5B gene polymorphism, rs35705950-T, is associated
with idiopathic pulmonary fibrosis, but its role in the SARS-CoV-2 infection and disease
severity is unclear. Objectives To assess whether rs35705950-T confers differential risk for
clinical outcomes associated with COVID-19 infection among participants in the Million
Veteran Program (MVP) and COVID-19 Host Genetics Initiative (HGI). Methods MVP
participants were examined for an association between the incidence or severity of COVID …

Rationale: A common MUC5B gene polymorphism, rs35705950-T, is associated with
idiopathic pulmonary fibrosis (IPF), but its role in severe acute respiratory syndrome
coronavirus 2 infection and disease severity is unclear. Objectives: To assess whether
rs35705950-T confers differential risk for clinical outcomes associated with coronavirus
disease (COVID-19) infection among participants in the Million Veteran Program (MVP).
Methods: The MUC5B rs35705950-T allele was directly genotyped among MVP participants; …