OBJECTIVE: To determine the contribution of the surfactant protein C (SP-C) I73T mutation
to lung disease. STUDY DESIGN: Genomic DNA was obtained from 116 children with
interstitial lung disease (ILD) or chronic lung disease of unclear cause and from 166 control
subjects and was screened for the I73T mutation using an allele-specific polymerase chain
reaction assay. RESULTS: The I73T mutation was found on 7 of 232 SP-C alleles from 7
unrelated children with ILD but was not found on 332 control SP-C alleles (P<. 01, Fisher …

A common mutation in the surfactant protein C gene associated wit lung disease | CiNii
Research … A common mutation in the surfactant protein C gene associated wit lung disease …