The major challenge in the existing healthcare industry of Pakistan is that despite the presence of extensive data and related information, there is no solid Knowledge Management (KM) process or framework for controlling and catering the diversified nature of knowledge creation for effective decision making resulting in ineffective and inefficient organization and utilization of various important resources being used during the decision making operations [12] [13]. In this study, we present and suggest a comprehensive and phased knowledge management process framework that integrates and streamlines varied and multiple processes in a phased manner to collect, analyze and manage knowledge and the knowledge creation process for supporting the effective decision making in healthcare information systems related to healthcare industry of Pakistan. This KM process framework will help identify the information needs and provide decision makers with useful step-by-step recommendations and guidelines based upon the integrated knowledge and past experience.