In the food industry, food quality and safety are of prime concern and the proper packaging technology can significantly ensure the quality for final consumers. Therefore, innovation in food packaging technology is believed to cater to the rising global demand for food quality and safety. The application of CRISPR technology for the ultra-sensitive diagnosis of pathogens and food contaminants present in the headspace of packaged food can be an emerging strategy to protect consumers' health. Moreover, exploring a brief technological aspect of how deep learning empowered food quality inspection may provide global food safety and lead to a healthy secured environment. According to WHO, an estimated 600 million individuals, or about 1 in 10 people, each year become ill due to consuming contaminated food, which causes 420000 deaths and the loss of 33 million healthy life years (DALYs). In this context, the current research focuses on enhancing food safety and quality by utilizing novel approaches. CRISPR-based intelligent packaging technology is thus believed to pave the route for food industries as the real-time surveillance system of food contaminants. This review illustrates the technological advancement with traceability, computing automation, and big-data analysis that can be an alternative approach to circumvent the paucity of existing packaging analytics. Additionally, the infusion of CRISPR technology with interconnected disciplines may ignite a novel ray of hope in the next-generation packaging sector.