A controlled trial of tacrine in Alzheimer's disease
M Farlow, SI Gracon, LA Hershey, KW Lewis… - Jama, 1992 - jamanetwork.com
Objective.—To compare efficacy and safety of tacrine hydrochloride with placebo in patients
with probable Alzheimer's disease. Design.—A 12-week, double-blind, placebo-controlled,
parallel-group study. Setting.—Outpatients at 23 centers. Patients.—Men and women with
probable Alzheimer's disease, at least 50 years old, mildly to moderately impaired, without
other significant medical conditions. Interventions.—In the initial 6 weeks, patients received
placebo, 20 mg/d of tacrine, or 40 mg/d of tacrine. In the second 6 weeks, half received the …
with probable Alzheimer's disease. Design.—A 12-week, double-blind, placebo-controlled,
parallel-group study. Setting.—Outpatients at 23 centers. Patients.—Men and women with
probable Alzheimer's disease, at least 50 years old, mildly to moderately impaired, without
other significant medical conditions. Interventions.—In the initial 6 weeks, patients received
placebo, 20 mg/d of tacrine, or 40 mg/d of tacrine. In the second 6 weeks, half received the …
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