A convenient synthesis of coumarin-3-thiocarboxamides

JSA Brunskill, A De, Z Elagbar, H Jeffrey… - Synthetic …, 1978 - Taylor & Francis
JSA Brunskill, A De, Z Elagbar, H Jeffrey, DF Ewing
Synthetic Communications, 1978Taylor & Francis
Coumarins possess a wide range of pharmacological and antimicrobial activities2 and in
many compounds of medicinal interest, both from natural3 and synthetic sources4, the
pyrone ring forms part of a polynuclear system. The amide and thioamide functions5 also
play a significant role in several physiological processes. We wish to report a convenient
preparative method for hitherto unknown compounds with both these structural features.
Abstract
Coumarins possess a wide range of pharmacological and antimicrobial activities2 and in many compounds of medicinal interest, both from natural3 and synthetic sources4, the pyrone ring forms part of a polynuclear system. The amide and thioamide functions5 also play a significant role in several physiological processes. We wish to report a convenient preparative method for hitherto unknown compounds with both these structural features.
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