A convenient synthesis of linezolid through Buchwald-Hartwig amination
A new method was developed for the synthesis of Linezolid from commercially available (R)-
3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl) oxazolidin-2-one. Linezolid is an antibiotic
belongs to the family of oxazolidinones, it is successfully synthesized through a new method
which include Buchwald-Hartwig amination reaction and Gabriel amine synthesis as the key
steps. The synthetic route is easy to perform and with high yield. This new method provides
a huge possibility for the synthesis of new linezolid derivatives that may possibly tackle the …
3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl) oxazolidin-2-one. Linezolid is an antibiotic
belongs to the family of oxazolidinones, it is successfully synthesized through a new method
which include Buchwald-Hartwig amination reaction and Gabriel amine synthesis as the key
steps. The synthetic route is easy to perform and with high yield. This new method provides
a huge possibility for the synthesis of new linezolid derivatives that may possibly tackle the …
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