A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons
A Sybirna, WWC Tang, M Pierson Smela… - Nature …, 2020 - nature.com
PRDM14 is a crucial regulator of mouse primordial germ cells (mPGCs), epigenetic
reprogramming and pluripotency, but its role in the evolutionarily divergent regulatory
network of human PGCs (hPGCs) remains unclear. Besides, a previous knockdown study
indicated that PRDM14 might be dispensable for human germ cell fate. Here, we decided to
use inducible degrons for a more rapid and comprehensive PRDM14 depletion. We show
that PRDM14 loss results in significantly reduced specification efficiency and an aberrant …
reprogramming and pluripotency, but its role in the evolutionarily divergent regulatory
network of human PGCs (hPGCs) remains unclear. Besides, a previous knockdown study
indicated that PRDM14 might be dispensable for human germ cell fate. Here, we decided to
use inducible degrons for a more rapid and comprehensive PRDM14 depletion. We show
that PRDM14 loss results in significantly reduced specification efficiency and an aberrant …
[引用][C] A critical role of PRDM14 in human primordial germ cell fate revealed by inducible degrons. Nat. Commun. 11, 1282
A Sybirna, WWC Tang, M Pierson Smela, S Dietmann… - 2020
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