Purpose Children with acute lymphoblastic leukemia (ALL) are at increased risk of vitamin D
deficiency, which might make them more susceptible to developing adverse events.
Previous studies showed that low vitamin D levels were associated with an increased
inflammatory mucosal state and impaired mucosal tissue barriers. We examined the
prevalence of vitamin D deficiency and studied the association between vitamin D levels
and methotrexate (MTX)-induced oral mucositis in pediatric ALL. Methods We assessed 25 …

INTRODUCTION Children with acute lymphoblastic leukemia (ALL) are at increased risk of
vitamin D deficiency, which might make them more susceptible to developing adverse
events. Previous studies showed that the vitamin D receptor is expressed in the mucosa and
that a relation exists between low vitamin D levels and an increased inflammatory mucosal
state and impaired mucosal tissue barriers. We examined the prevalence of vitamin D
deficiency and the change in vitamin D levels in children with ALL during high-dose …