E-cadherin is a major adherens junction protein of epithelial cells, with a central role in cell-
cell adhesion and cell polarity. Newly synthesized E-cadherin is targeted to the basolateral
cell surface. We analyzed targeting information in the cytoplasmic tail of E-cadherin by
utilizing chimeras of E-cadherin fused to the ectodomain of the interleukin-2α (IL-2α)
receptor expressed in Madin-Darby canine kidney and LLC-PK 1 epithelial cells. Chimeras
containing the full-length or membrane-proximal half of the E-cadherin cytoplasmic tail were …