The main task of skeletal muscle is contraction and relaxation for body movement and
posture maintenance. During contraction and relaxation, Ca 2+ in the cytosol has a critical
role in activating and deactivating a series of contractile proteins. In skeletal muscle, the
cytosolic Ca 2+ level is mainly determined by Ca 2+ movements between the cytosol and
the sarcoplasmic reticulum. The importance of Ca 2+ entry from extracellular spaces to the
cytosol has gained significant attention over the past decade. Store-operated Ca 2+ entry …

The main task of skeletal muscle is contraction and relaxation for body movement and
posture maintenance. During contraction and relaxation, Ca2+ in the cytosol has a critical
role in activating and deactivating a series of contractile proteins. In skeletal muscle, the
cytosolic Ca2+ level is mainly determined by Ca2+ movements between the cytosol and the
sarcoplasmic reticulum. The importance of Ca2+ entry from extracellular spaces to the
cytosol has gained significant attention over the past decade. Store-operated Ca2+ entry …