A gamut of undiscovered electrophysiological effects produced by Tityus serrulatus toxin 1 on NaV-type isoforms
S Peigneur, CT Cologna, CM Cremonez, BG Mille… - …, 2015 - Elsevier
In the last decades, Ts1 has not only been the subject of many studies, it has also been
considered as a very useful tool to investigate Na V channels and to explore the exact role of
Na V channels in channelopathies. Ts1 is believed to modulate the activation process of Na
V upon interaction at the neurotoxin binding site 4. Our aim was to carry out an in depth
functional characterization of Ts1 on a wide array of Na v channels, in order to investigate its
mechanism of action and to verify if Ts1 can indeed be considered as a prototype site 4 …
considered as a very useful tool to investigate Na V channels and to explore the exact role of
Na V channels in channelopathies. Ts1 is believed to modulate the activation process of Na
V upon interaction at the neurotoxin binding site 4. Our aim was to carry out an in depth
functional characterization of Ts1 on a wide array of Na v channels, in order to investigate its
mechanism of action and to verify if Ts1 can indeed be considered as a prototype site 4 …
[PDF][PDF] A gamut of undiscovered electrophysiological
abstract In the last decades, Ts1 has not only been the subject of many studies, it has also
been considered as a very useful tool to investigate NaV channels and to explore the exact
role of NaV channels in channelopathies. Ts1 is believed to modulate the activation process
of NaV upon interaction at the neurotoxin binding site 4. Our aim was to carry out an in depth
functional characterization of Ts1 on a wide array of Nav channels, in order to investigate its
mechanism of action and to verify if Ts1 can indeed be considered as a prototype site 4 …
been considered as a very useful tool to investigate NaV channels and to explore the exact
role of NaV channels in channelopathies. Ts1 is believed to modulate the activation process
of NaV upon interaction at the neurotoxin binding site 4. Our aim was to carry out an in depth
functional characterization of Ts1 on a wide array of Nav channels, in order to investigate its
mechanism of action and to verify if Ts1 can indeed be considered as a prototype site 4 …
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