Multiple aspects of Drosophila oogenesis, including germline stem cell activity, germ cell
differentiation, and follicle survival, are regulated by the steroid hormone ecdysone. While
the transcriptional targets of ecdysone signaling during development have been studied
extensively, targets in the ovary remain largely unknown. Early studies of salivary gland
polytene chromosomes led to a model in which ecdysone stimulates a hierarchical
transcriptional cascade, wherein a core group of ecdysone-sensitive transcription factors …