Context The efficacy of antidepressant drug treatment in depression is unsatisfactory; 1 in 3
patients does not fully recover even after several treatment trials. Genetic factors and clinical
characteristics contribute to the failure of a favorable treatment outcome. Objective To
identify genetic and clinical determinants of antidepressant drug treatment outcome in
depression. Design Genomewide pharmacogenetic association study with 2 independent
replication samples. Setting We performed a genomewide association study in patients from …