Mainstreaming represents an integrated, cross government agency approach to incorporating an issue into programmes and policies. Mainstreaming of resource efficiency and sustainable consumption and production (SCP and RE) has been identified to be essential to ensuring the development of policies, programmes, actions and initiatives with a wider reaching set of outcomes than if these were to be undertaken on their own. This paper outlines a guidance framework which was developed to support practitioners, champions and UN support teams on mainstreaming of SCP and RE. The framework is based on the programmatic approach to environmental mainstreaming which has been developed through wide-ranging experience on other environment and poverty-environment related topics. The approach presented here is not linear, and each of the elements requires ongoing evaluation and updating. In addition, it is identified that mainstreaming of SCP and RE should form part of overall environmental mainstreaming efforts. Furthermore, unless a country has already developed a national SCP programme, the development of such a programme and the mainstreaming process discussed in this current document should be done in parallel, not as separate processes.