The addition of a lipid moiety to a protein increases its hydrophobicity and subsequently its
attraction to lipophilic environments like membranes. Indeed most lipid‐modified proteins
are localized to membranes where they associate with multiprotein signaling complexes.
Acylation and prenylation are the two common categories of lipidation. The enzymology and
pharmacology of prenylation are well understood but relatively very little is known about
palmitoylation, the most common form of acylation. One distinguishing characteristic of …