A model of motor and sensory axon activation in the median nerve using surface electrical stimulation

JL Gaines, KE Finn, JP Slopsema, LA Heyboer… - Journal of computational …, 2018 - Springer
Journal of computational neuroscience, 2018Springer
Surface electrical stimulation has the potential to be a powerful and non-invasive treatment
for a variety of medical conditions but currently it is difficult to obtain consistent evoked
responses. A viable clinical system must be able to adapt to variations in individuals to
produce repeatable results. To more fully study the effect of these variations without
performing exhaustive testing on human subjects, a system of computer models was created
to predict motor and sensory axon activation in the median nerve due to surface electrical …
Abstract
Surface electrical stimulation has the potential to be a powerful and non-invasive treatment for a variety of medical conditions but currently it is difficult to obtain consistent evoked responses. A viable clinical system must be able to adapt to variations in individuals to produce repeatable results. To more fully study the effect of these variations without performing exhaustive testing on human subjects, a system of computer models was created to predict motor and sensory axon activation in the median nerve due to surface electrical stimulation at the elbow. An anatomically-based finite element model of the arm was built to accurately predict voltages resulting from surface electrical stimulation. In addition, two axon models were developed based on previously published models to incorporate physiological differences between sensory and motor axons. This resulted in axon models that could reproduce experimental results for conduction velocity, strength-duration curves and activation threshold. Differences in experimentally obtained action potential shape between the motor and sensory axons were reflected in the models. The models predicted a lower threshold for sensory axons than motor axons of the same diameter, allowing a range of sensory axons to be activated before any motor axons. This system of models will be a useful tool for development of surface electrical stimulation as a method to target specific neural functions.
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