Pulmonary arteries constitute a low-pressure network of vessels, often characterized as a
bifurcating tree with heterogeneous vessel mechanics. Understanding the vascular
complexity and establishing homeostasis is important to study diseases such as pulmonary
arterial hypertension (PAH). The onset and early progression of PAH can be traced to
changes in the morphometry and structure of the distal vasculature. Coupling
hemodynamics with vessel wall growth and remodeling (G&R) is crucial for understanding …

Coupling hemodynamics with vessel wall growth and remodeling (G&R) is crucial for
understanding pathology at distal vasculature to study progression of incurable vascular
diseases, such as pulmonary arterial hypertension. The present study is the first modeling
attempt that focuses on defining homeostatic baseline values in distal pulmonary vascular
bed via, a so-called, homeostatic optimization. To define the vascular homeostasis and total
hemodynamics in the vascular tree, we consider two time-scales: a cardiac cycle and a …