A mycobacterial phosphoribosyltransferase promotes bacillary survival by inhibiting oxidative stress and autophagy pathways in macrophages and zebrafish
S Mohanty, L Jagannathan, G Ganguli, A Padhi… - Journal of Biological …, 2015 - ASBMB
Mycobacterium tuberculosis employs various strategies to modulate host immune responses
to facilitate its persistence in macrophages. The M. tuberculosis cell wall contains numerous
glycoproteins with unknown roles in pathogenesis. Here, by using Concanavalin A and LC-
MS analysis, we identified a novel mannosylated glycoprotein phosphoribosyltransferase,
encoded by Rv3242c from M. tuberculosis cell walls. Homology modeling, bioinformatic
analyses, and an assay of phosphoribosyltransferase activity in Mycobacterium smegmatis …
to facilitate its persistence in macrophages. The M. tuberculosis cell wall contains numerous
glycoproteins with unknown roles in pathogenesis. Here, by using Concanavalin A and LC-
MS analysis, we identified a novel mannosylated glycoprotein phosphoribosyltransferase,
encoded by Rv3242c from M. tuberculosis cell walls. Homology modeling, bioinformatic
analyses, and an assay of phosphoribosyltransferase activity in Mycobacterium smegmatis …
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