A neonatal piglet model for investigating brain and cognitive development in small for gestational age human infants
The piglet was investigated as a potential model for studying brain and cognitive deficits
associated with being born small for gestational age (SGA). Naturally farrowed SGA (0.7–1.0
kg BW) and average for gestational age (AGA, 1.3–1.6 kg BW) piglets were obtained on
postnatal day (PD) 2, placed in individual cages, and provided a nutritionally adequate milk
replacer diet (285 ml/kg/d). Beginning at PD14, performance in a spatial T-maze task was
assessed. At PD28, piglets were anesthetized for magnetic resonance (MR) imaging to …
associated with being born small for gestational age (SGA). Naturally farrowed SGA (0.7–1.0
kg BW) and average for gestational age (AGA, 1.3–1.6 kg BW) piglets were obtained on
postnatal day (PD) 2, placed in individual cages, and provided a nutritionally adequate milk
replacer diet (285 ml/kg/d). Beginning at PD14, performance in a spatial T-maze task was
assessed. At PD28, piglets were anesthetized for magnetic resonance (MR) imaging to …
145. A neonatal piglet model for investigating brain and cognitive development in small for gestational age human infants
EC Radlowski, MS Conrad, S Lezmi, RN Dilger… - Brain, Behavior, and …, 2014 - Elsevier
The piglet was investigated as a model for studying brain and cognitive deficits associated
with being born small for gestational age (SGA). Naturally farrowed SGA (0.7–1.0 kg BW)
and average for gestational age (AGA, 1.3–1.6 kg BW) piglets were obtained on postnatal
day (PD) 2, placed in individual cages, and provided a nutritionally adequate milk replacer
(285 ml/kg/d). At PD14, performance in a spatial T-maze was assessed. At PD28, piglets
underwent magnetic resonance (MR) imaging to assess brain structure (voxel-based …
with being born small for gestational age (SGA). Naturally farrowed SGA (0.7–1.0 kg BW)
and average for gestational age (AGA, 1.3–1.6 kg BW) piglets were obtained on postnatal
day (PD) 2, placed in individual cages, and provided a nutritionally adequate milk replacer
(285 ml/kg/d). At PD14, performance in a spatial T-maze was assessed. At PD28, piglets
underwent magnetic resonance (MR) imaging to assess brain structure (voxel-based …
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