A network model of early events in epidermal growth factor receptor signaling that accounts for combinatorial complexity
We consider a model of early events in signaling by the epidermal growth factor (EGF)
receptor (EGFR). The model includes EGF, EGFR, the adapter proteins Grb2 and Shc, and
the guanine nucleotide exchange factor Sos, which is activated through EGF-induced
formation of EGFR–Grb2–Sos and EGFR–Shc–Grb2–Sos assemblies at the plasma
membrane. The protein interactions involved in signaling can potentially generate a diversity
of protein complexes and phosphoforms; however, this diversity has been largely ignored in …
receptor (EGFR). The model includes EGF, EGFR, the adapter proteins Grb2 and Shc, and
the guanine nucleotide exchange factor Sos, which is activated through EGF-induced
formation of EGFR–Grb2–Sos and EGFR–Shc–Grb2–Sos assemblies at the plasma
membrane. The protein interactions involved in signaling can potentially generate a diversity
of protein complexes and phosphoforms; however, this diversity has been largely ignored in …
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