A novel fluorescent imaging agent for diffuse optical tomography of the breast: first clinical experience in patients

S van de Ven, A Wiethoff, T Nielsen, B Brendel… - Molecular imaging and …, 2010 - Springer
S van de Ven, A Wiethoff, T Nielsen, B Brendel, M van der Voort, R Nachabe
Molecular imaging and biology, 2010Springer
Purpose This is the first clinical evaluation of a novel fluorescent imaging agent
(Omocianine) for breast cancer detection with diffuse optical tomography (DOT). Procedures
Eleven women suspected of breast cancer were imaged with DOT at multiple time points (up
to 24 h) after receiving an intravenous injection of Omocianine (doses 0.01 to 0.1 mg/kg
bodyweight). Breast MRI was obtained for comparison. Results Histopathology showed
invasive cancer in ten patients and fibroadenoma in one patient. With the lowest dose of …
Purpose
This is the first clinical evaluation of a novel fluorescent imaging agent (Omocianine) for breast cancer detection with diffuse optical tomography (DOT).
Procedures
Eleven women suspected of breast cancer were imaged with DOT at multiple time points (up to 24 h) after receiving an intravenous injection of Omocianine (doses 0.01 to 0.1 mg/kg bodyweight). Breast MRI was obtained for comparison.
Results
Histopathology showed invasive cancer in ten patients and fibroadenoma in one patient. With the lowest dose of Omocianine, two of three lesions were detected; with the second dose, three of three lesions were detected; with the two highest doses, none of five lesions were detected. Lesion location on DOT showed excellent agreement with MRI. Optimal lesion-to-background signals were obtained after 8 h. No adverse events occurred.
Conclusions
Lowest doses of Omocianine performed best in lesion detection; DOT using a low-dose fluorescent agent is feasible and safe for breast cancer visualization in patients.
Springer
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