A pan-cancer analysis of secreted Frizzled-related proteins: re-examining their proposed tumour suppressive function
KM Vincent, LM Postovit - Scientific reports, 2017 - nature.com
Secreted frizzled-related proteins (SFRPs), containing five family members (SFRPs 1–5) are
putative extracellular Wnt inhibitors. Given their abilities to inhibit Wnt signalling, as well as
the loss of SFRP1 in many cancers, this family is generally considered to be tumour
suppressive. In this study we analyzed gene expression, promoter methylation and survival
data from over 8000 tumour and normal samples from 29 cancers in order to map the
context-specific associations of SFRPs 1–5 with patient survival, gene silencing and gene …
putative extracellular Wnt inhibitors. Given their abilities to inhibit Wnt signalling, as well as
the loss of SFRP1 in many cancers, this family is generally considered to be tumour
suppressive. In this study we analyzed gene expression, promoter methylation and survival
data from over 8000 tumour and normal samples from 29 cancers in order to map the
context-specific associations of SFRPs 1–5 with patient survival, gene silencing and gene …