A pragmatic randomized feasibility trial of influenza vaccines
Background The relative vaccine effectiveness (rVE) of high-dose quadrivalent influenza
vaccines (QIV-HD) versus standard-dose quadrivalent influenza vaccines (QIV-SD) against
hospitalizations and mortality in the general older population has not been evaluated in an
individually randomized trial. Because of the large sample size required, such a trial will
need to incorporate innovative, pragmatic elements. Methods We conducted a pragmatic,
open-label, active-controlled, randomized feasibility trial in Danish citizens aged 65 to 79 …
vaccines (QIV-HD) versus standard-dose quadrivalent influenza vaccines (QIV-SD) against
hospitalizations and mortality in the general older population has not been evaluated in an
individually randomized trial. Because of the large sample size required, such a trial will
need to incorporate innovative, pragmatic elements. Methods We conducted a pragmatic,
open-label, active-controlled, randomized feasibility trial in Danish citizens aged 65 to 79 …
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