The large size and vascular accessibility of the laboratory rat (Rattus norvegicus) make it an
ideal hepatic animal model for diseases that require surgical manipulation. Often, the
disease susceptibility and outcomes of inflammatory pathologies vary significantly between
strains. This study uses single-cell transcriptomics to better understand the complex cellular
network of the rat liver, as well as to unravel the cellular and molecular sources of inter-strain
hepatic variation. We generated single-cell and single-nucleus transcriptomic maps of the …