A regulatory cascade controls Staphylococcus aureus pathogenicity island activation
Staphylococcal pathogenicity islands (SaPIs) are a family of closely related mobile
chromosomal islands that encode and disseminate the superantigen toxins, toxic shock
syndrome toxin 1 and superantigen enterotoxin B (SEB). They are regulated by master
repressors, which are counteracted by helper phage–encoded proteins, thereby inducing
their excision, replication, packaging and intercell transfer. SaPIs are major components of
the staphylococcal mobilome, occupying five chromosomal att sites, with many strains …
chromosomal islands that encode and disseminate the superantigen toxins, toxic shock
syndrome toxin 1 and superantigen enterotoxin B (SEB). They are regulated by master
repressors, which are counteracted by helper phage–encoded proteins, thereby inducing
their excision, replication, packaging and intercell transfer. SaPIs are major components of
the staphylococcal mobilome, occupying five chromosomal att sites, with many strains …
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